{"id":125,"ordering":7015.0,"pdbid":"1rsy","name":"Synaptotagmin-1","description":null,"comments":"N-terminal residues originating from expression vector have been removed during calculations. ","resolution":"1.9","topology_subunit":"","topology_show_in":true,"thickness":2.5,"thicknesserror":1.6,"subunit_segments":0,"tilt":24,"tilterror":17,"gibbs":-4.1,"tau":"","verification":"Side-chains of residues in positions M173, G174, and F234 penetrate into the hydrophobic core of the membrane in the calculated orientation. Experimental membrane depth parameters are positive in positions 174 and 234 (only) but negative in position 173 (Table 2 in Frazier et al. 2003). However, residue M173 was identified as most important for membrane binding by Gerber et al. (2002).","family_name_cache":"C2 domain","species_name_cache":"Rattus norvegicus","membrane_name_cache":"Eykaryo. plasma","membrane_id":4,"species_id":54,"family_id":60,"superfamily_id":45,"classtype_id":3,"type_id":2,"secondary_representations_count":0,"structure_subunits_count":0,"citations_count":0,"uniprotcodes":["SYT1_RAT"],"family":{"id":60,"name":"C2 domain","pfam":"PF00168","interpro":"IPR000008","tcdb":"","primary_structures_count":60,"superfamily":{"id":45,"name":"C2 domain","pfam":"CL0154","tcdb":"","families_count":1,"classtype":{"id":3,"name":"All beta monotopic/peripheral","superfamilies_count":60,"type":{"id":2,"name":"Monotopic/peripheral","classtypes_count":4}}}},"species":{"id":54,"name":"Rattus norvegicus","description":"Eukaryota, Opisthokonta, Metazoa, Eumetazoa, Bilateria, Deuterostomia, Chordata, Craniata, Vertebrata, Gnathostomata (jawed vertebrates), Teleostomi, Euteleostomi, Sarcopterygii, Dipnotetrapodomorpha, Tetrapoda, Amniota, Mammalia, Theria, Eutheria, Boreoeutheria, Euarchontoglires, Glires (Rodents and rabbits), Rodentia, Myomorpha (mice and others), Muroidea, Muridae, Murinae","primary_structures_count":363},"membrane":{"id":4,"name":"Eukaryotic plasma membrane","primary_structures_count":3316,"short_name":"Eykaryo. plasma","abbrevation":null,"topology_in":"cytoplasmic side","topology_out":"extracellular side","lipid_references":"Ingolfsson, H. I., M. N. Melo, F. J. van Eerden, C. Arnarez, C. A. Lopez, T. A. Wassenaar, X. Periole, A. H. de Vries, D. P. Tieleman and S. J. Marrink (2014). \"Lipid organization of the plasma membrane.\" J Am Chem Soc 136(41): 14554-14559.; Rivel, T., C. Ramseyer and S. Yesylevskyy (2019). \"The asymmetry of plasma membranes and their cholesterol content influence the uptake of cisplatin.\" Sci Rep 9(1): 5627.","lipid_pubmed":"25229711;30948733"},"subunits":[],"secondary_representations":[],"citations":[]}